Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy
查看参考文献25篇
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文摘
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Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy. |
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来源
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Neural Regeneration Research
,2011,6(10):785-789 【核心库】
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DOI
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10.3969/j.issn.1673-5374.2011.10.011
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关键词
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umbilical cord mesenchymal stem cells
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Duchenne muscular dystrophy
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case report
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dystrophin
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muscular force
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activities of daily living
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地址
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Cell Treatment Center,Chinese PLA 463 Hospital, Liaoning, Shenyang, 110042
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语种
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英文 |
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文献类型
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简报 |
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ISSN
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1673-5374 |
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学科
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中国医学 |
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基金
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Key Projects of Liaoning Province
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文献收藏号
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CSCD:4258073
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参考文献 共
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