ZnHA/TiO_2复合涂层的制备及生物相容性
PREPARATION AND BIOCOMPATIBILITY OF ZnHA/TiO_2 HYBRID COATING
查看参考文献26篇
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文摘
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为改善羟基磷灰石(HA)涂层与Ti基体的结合性能及成骨性能,在纯Ti表面先通过微弧氧化方法形成多孔TiO_2,然后通过溶胶凝胶法在其上形成ZnHA生物涂层.利用SEM和XRD观察和分析样品的表面形貌和物相组成,采用火焰原子吸收分光光度法测量Zn~(2+)的释放浓度.将MG-63细胞直接接种于样品表面,评价成骨细胞在样品表面的黏附和增殖.噻唑蓝(MTT)比色分析结果表明,细胞在ZnHA/TiO_2-2和ZnHA/TiO_2-3涂层的样品表面增殖率比对照组(HA)显著增加,倒置荧光显微镜下可观察到细胞在改性样品表面黏附和伸展良好.由此表明,带有ZnHA/TiO_2复合涂层的Ti种植体应具有更好的机械结合性能和生物相容性 |
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其他语种文摘
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To improve the binding and osteogenic properties for the hydroxyapatite(HA) coating on Ti substrate,a ZnHA biological coating was prepared on commercially pure Ti by sol-gel method after a treatment by micro-arc oxidation(MAO) to produce an porous titania(TiO_2) coating on Ti. The morphologies and phases components of the coating were characterized by SEM and XRD.The release concentration of Zn~(2+) was measured by flame atomic absorption spectrometry. In vitro coculture assays were performed to evaluate the cell proliferation and adhesion of MG-63 cells to the coated Ti.The proliferation rates of the cells were found to be significantly higher on the ZnHA/TiO_2- 2 and ZnHA/TiO_2-3 coatings than that of the control group(HA) by MTT.It was confirmed by the fluorescence microscopy observations that the osteoblast-like cells on the hybrid coating were favorably adhered and spread. The results suggest that the ZnHA/TiO_2 hybrid coatings on Ti implants should possess better binding property and biocompatibility |
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来源
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金属学报
,2011,47(4):429-434 【核心库】
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DOI
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10.3724/sp.j.1037.2010.00448
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关键词
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Zn
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Ti
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TiO_2
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羟基磷灰石
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成骨细胞
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生物相容性
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地址
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1.
中国医科大学口腔医学院, 沈阳, 110001
2.
大连理工大学材料科学与工程学院, 大连, 116024
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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0412-1961 |
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学科
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金属学与金属工艺 |
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文献收藏号
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CSCD:4181880
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参考文献 共
26
共2页
|
|
1.
Hing K A.
J Mater Sci: Mater Med,1999,10:135
|
CSCD被引
14
次
|
|
|
|
|
2.
Kay J F.
Dent Clin North Am,1992,36:1
|
CSCD被引
2
次
|
|
|
|
|
3.
Elliott J C.
Structure and Chemistry of the Apatites and Other Calcium Orthophosphates,1994:387
|
CSCD被引
1
次
|
|
|
|
|
4.
Koutsopoulos S.
J Biomed Mater Res,2002,62:600
|
CSCD被引
38
次
|
|
|
|
|
5.
Ito A.
Curr Appl Phys,2005,5:402
|
CSCD被引
3
次
|
|
|
|
|
6.
Legeros R Z.
US Pat, 20090068285,2009
|
CSCD被引
1
次
|
|
|
|
|
7.
Bigi A.
J Inorg Biochem,1995,58:49
|
CSCD被引
2
次
|
|
|
|
|
8.
Miyaji F.
Mater Res Bull,2005,40:209
|
CSCD被引
10
次
|
|
|
|
|
9.
Hayakawa S.
J Am Ceram Soc,2007,90:565
|
CSCD被引
2
次
|
|
|
|
|
10.
Li M O.
J Mater Sci: Mater Med,2008,19:797
|
CSCD被引
1
次
|
|
|
|
|
11.
Ramaswamy Y.
J Acta Biomaterial,2008,4:1487
|
CSCD被引
1
次
|
|
|
|
|
12.
Yao Z Q.
Acta Biomater,2010,6:2816
|
CSCD被引
19
次
|
|
|
|
|
13.
Cheng K.
Mater Chem Phys,2003,78:767
|
CSCD被引
4
次
|
|
|
|
|
14.
Le Gue'hennec L.
Dent Mater,2007,23:844
|
CSCD被引
1
次
|
|
|
|
|
15.
Buser D.
J Biomed Mater Res,1991,25:889
|
CSCD被引
15
次
|
|
|
|
|
16.
Albrektsson T.
Int J Prosthodont,2004,17:536
|
CSCD被引
14
次
|
|
|
|
|
17.
Wang Y M.
Surf Coat Technol,2006,201:82
|
CSCD被引
20
次
|
|
|
|
|
18.
Li L H.
Biomaterials,2004,25:2867
|
CSCD被引
59
次
|
|
|
|
|
19.
Ryu H S.
Surf Coat Technol,2008,202:1853
|
CSCD被引
5
次
|
|
|
|
|
20.
Nie X.
J Biomed Mater Res,2001,57:612
|
CSCD被引
13
次
|
|
|
|
|
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