MAGNOLOL ENTRAPPED ULTRA-FINE FIBROUS MATS ELECTROSPUN FROM POLY(ETHYLENE GLYCOL)-b-POLY(L-LACTIDE) AND IN VITRO RELEASE
查看参考文献14篇
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文摘
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Ultra-fine fibrous mats with magnolol entrapped have been prepared by electrospinning biodegradable copolymer poly(ethylene glycol) blocked poly(L-lactide). Drug entrapment was perfect which was confirmed by scanning electron microscopy and differential scanning calorimetry. According to in vitro drug release investigation by high performance liquid chromatography, it was found that fibers with 10%, 20% and 30% drug entrapped respect to polymer (mass ratio) presented dramatically different drug release behavior and degradation behavior under the effect of proteinase K. The reason may be that fibers with 10% drug entrapped was more easily affected by enzyme while, to some degree, magnolol in fibers with 20% and 30% entrapped prevented polymer from being degraded by enzyme |
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来源
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Chinese Journal of Polymer Science
,2011,29(2):173-179 【核心库】
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DOI
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10.1007/s10118-011-1024-z
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关键词
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Medicated fiber
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Electrospinning
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Drug release
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Poly(ethylene glycol)
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Polylactide
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Magnolol
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Proteinase K
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地址
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1.
School of Pharmacy, Shenyang Pharmaceutical University, State Key Laboratory of Polymer Chemistry and Physics, Shenyang, 110016
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School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016
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School of Life Science and Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016
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School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016
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Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, State Key Laboratory of Polymer Chemistry and Physics, Changchun, 130022
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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0256-7679 |
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学科
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化学工业 |
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基金
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国家自然科学基金
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中国科学院项目
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文献收藏号
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CSCD:4144350
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