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Design, synthesis and biological evaluation of novel glucokinase activators
查看参考文献10篇
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文摘
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A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675 |
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来源
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Chinese Chemical Letters
,2011,22(1):73-76 【核心库】
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DOI
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10.1016/j.cclet.2010.07.023
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关键词
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Diabetes
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Glucokinase activators
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Benzamide derivatives
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地址
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1.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050
2.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1001-8417 |
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学科
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化学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:4122342
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