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Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis

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Liu Jiali 1   Liang Yuan 2   Wang Zhenning 1 *   Zhou Xin 3   Xing Lili 4  
文摘 AIM: To investigate the association of the cyclooxygenases-2(COX-2)polymorphisms and susceptibility to gastric cancer(GC)by means of meta-analysis. METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE,EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR)with 95%confidence interval(CI)was calculated. RESULTS: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C,-1195A, -1290G,*2430T alleles and*429TT genotype revealed increased risk for GC(OR=1.71,95%CI:1.01-2.90,P =0.05;OR=1.58,95%CI:1.05-2.38,P=0.03;OR= 1.55,95%CI:1.01-2.39,P=0.05;OR=2.62,95%CI: 1.20-5.73,P=0.02 and OR=0.74,95%CI:0.59-0.95, P=0.02, respectively). CONCLUSION: The-765C,-1195A,-1290G,*2430T alleles and*429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC
来源 World Journal of Gastroenterology ,2010,16(43):5510-5517 【核心库】
关键词 Cyclooxygenases-2 ; Gastric cancer ; Polymorphisms ; Susceptibility ; Meta-analysis
地址

1. Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001  

2. Department of Oncology, the Shengjing Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001  

3. Department of Obstetrics and Gynecology, the Shengjing Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110001  

4. Department of Oncology, the Fourth Affiliated Hospital of China Medical University, Liaoning, Shenyang, 110032

语种 英文
文献类型 研究性论文
ISSN 1007-9327
学科 内科学
基金 国家自然科学基金 ;  key laboratory programme of Education Department of Liaoning Province
文献收藏号 CSCD:4051416

参考文献 共 38 共2页

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引证文献 1 篇

1 李红霞 陕西人群环氧化酶-2(COX-2)启动子区基因多态性及与结直肠癌易感性的关联研究 西安交通大学学报. 医学版,2014,35(4):522-526,550
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