Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
查看参考文献38篇
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文摘
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The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site |
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来源
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Neural Regeneration Research
,2010,5(17):1296-1302 【核心库】
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DOI
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10.3969/j.issn.1673-5374.2010.17.003
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关键词
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bone marrow-derived mesenchymal stem cells
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cerebral ischemia/reperfusion
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survivin
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caspase-3
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cell apoptosis
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brain injury
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neural regeneration
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地址
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1.
Department of Neurology, Shengjing Hospital, China Medical University, Liaoning, Shenyang, 110004
2.
Department of Cadre Diagnosis and Treatment, First Hospital of China Medical University, Liaoning, Shenyang, 110002
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Department of Neurology, First Hospital of China Medical University, Liaoning, Shenyang, 110002
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1673-5374 |
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学科
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神经病学与精神病学 |
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基金
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a Grant from the Liaoning Provincial Education Department
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文献收藏号
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CSCD:4041464
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