大鼠空间记忆与吗啡戒断诱发条件性位置厌恶的相关研究
The correlation study on spatial memory and acute morphine withdrawal-induced conditioned place aversive in rats
查看参考文献10篇
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文摘
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目的 探讨急性吗啡戒断诱发的条件性位置厌恶效应(CPA)与动物在空间记忆任务表现上的个体差异之间的关系.方法 30只雄性Wistar大鼠在经历水迷宫空间任务后,依据其水迷宫探索任务成绩,分出高空间记忆组(n＝8)及低空间记忆组(n＝8),水迷宫任务结束后进行CPA训练,比较高、低空间记忆组动物CPA测试成绩上的差异.结果 作为分组标准,高低空间记忆组在水迷宫探索任务中,其原站台穿梭次数和停留时间上均存在与分组相一致的显著性差异,在经历后续的CPA训练后,CPA训练组动物形成了对戒断匹配环境的厌恶,其中高空间记忆组动物CPA测试成绩[(560.12±60.09)s,(333.00±150.25)s]高于低空间记忆组动物[(568.37±57.25)s,(471.37±130.67)s],组间差异有显著性(F=5.324,P＜0.05).结论 研究提示空间记忆提取过程与吗啡戒断的CPA效应存在部分相同的机制. |
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其他语种文摘
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Objective The present study attempted to investigate the correlation between individual differences of the capacities in spatial memory and the sensitivity to the conditioning aversive effect of the morphine withdrawal in rats. Methods Good memory(n＝8) and poor memory (n＝8)rats were respectively selected according to their performance in probe test in the Morris water maze, then both groups were trained with a place aversive conditioning procedure induced by morphine withdrawal with the saline control group. Results Good memory group and poor memory group showed significant difference in their time spent in trained quadrant and platform area during the probe test but no detectable difference in their performance in training task. In the CPA test, the aversive effect of the morphine withdrawal was highly in good memory group(560.12±60.09 vs 333.00±150.25)then in poor memory group(568.37±57.25 vs 471.37±130.67)and the difference was significant between groups by repeated measure with analysis of variance(F=5.324,P＜0.05). Conclusion These results suggest that the variation in morphine withdraw-induced CPA in rat is related to that of spatial memory. |
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来源
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中华行为医学与脑科学杂志
,2009,18(1):28-30 【扩展库】
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关键词
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吗啡戒断
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空间记忆
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条件性位置厌恶
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水迷宫
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地址
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中国科学院心理研究所, 中科院心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1674-6554 |
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学科
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基础医学 |
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基金
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国家973计划
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国家自然科学基金
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文献收藏号
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CSCD:3550860
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参考文献 共
10
共1页
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1.
Azar MR. Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal.
Psychopharmacology(Berlin),2003,170:42-50
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CSCD被引
12
次
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2.
刘彩谊. 地卓西平对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响.
中国行为医学科学,2007,16:315-317
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CSCD被引
1
次
|
|
|
|
|
3.
Lassalle JM. Reversible Inactivation of the Hippocampal Mossy Fiber Synapses in Mice Impairs Spatial Learning,but neither Consolidation nor Memory Retrieval,in the Morris Navigation Task.
NEUROBIOLOGY OF LEARNING AND MEMORY,2000,73:243-257
|
CSCD被引
1
次
|
|
|
|
|
4.
Xu N. Spatial learning and morphine-rewarded place preference negatively correlates in mice.
Pharmacology Biochemistry and Behavior,2001,68:389-394
|
CSCD被引
1
次
|
|
|
|
|
5.
White NM. Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions.
Behavioural Brain Research,1993,55:269-281
|
CSCD被引
1
次
|
|
|
|
|
6.
Phillips R. Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning.
Journal of Neuroscience,1995,15:5308-5315
|
CSCD被引
1
次
|
|
|
|
|
7.
oozendaal B. The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval:Dependence on the basolateral amygdala.
Proceedings of the National Academy of Sciences(USA),2003,100:1328-1333
|
CSCD被引
1
次
|
|
|
|
|
8.
Kim JJ. Amygdalar inactivation blocks stressinduced impairments in hippocampal long-term potentiation and spatial memory.
J Neurosci,2005,25:1532-1539
|
CSCD被引
4
次
|
|
|
|
|
9.
Jin C. Expression of c-Fos in the rat central amygdala accompanies the acquisition but not expression of conditioned place aversion induced by withdrawal from acute morphine dependence.
Behavioural Brain Research,2005,161:107-112
|
CSCD被引
2
次
|
|
|
|
|
10.
Nakagawa T. Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats.
NEUROSCIENCE,2005,134:9-19
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CSCD被引
1
次
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