伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用
The Roles of Orexins in the Nucleus Accumbens and Ventral Tegmental Area on Reward-Associated Behavior Induced by Morphine
查看参考文献21篇
文摘
|
实验采用条件性位置偏爱(CPP)模型考察中脑腹侧被盖区(VTA)和伏隔核壳区(NAeSh)内食欲素(orex-in)在吗啡奖赏中的作用.Wistar大鼠分为盐水训练组和吗啡训练组.3轮吗啡(或盐水)匹配训练前,双侧VTA或NAcSh内给予OXR1拮抗剂SB334867(VTA:0,1,5μg;NAcSh:0,1,3μg);或2轮吗啡(或盐水)匹配训练前NAcSh内给予orexin A(0,2,4,6μg),观察其对吗啡CPP建立的影响.结果表明,VTA内给予SB334867抑制吗啡CPP建立,并存在剂量效应关系;NAcSh内给予SB334867或orexin A均未影响吗啡CPP建立,而orexin A可增加吗啡处理大鼠的运动性.以上结果表明,VTA和NAcSh内的orexin在吗啡奖赏中扮演的角色不同,可能调控成瘾行为的不同成分. |
其他语种文摘
|
Orexins are neuropeptides produced by the hypothalamus. Orexin neurons have extensive projections to the mesolimbic dopamine system (MLSD) and are critically involved in drug addiction. The central nucleus of the MLSD, the ventral tegmental area (VTA) and nucleus accumbens (NAc), contain abundant orexinergic fibers and receptors. In the VTA, orexins are implicated in drug reward-elicited place preference and acquisition of behavioral sensitization. However, less study has been focused on the role of orexins in the NAc in drug reward by now. The present study aims to investigate the roles of orexins in the VTA and NAc in drug reward-associated behavior.The development of conditioned place preference (CPP) induced by morphine was used to investigate the roles of orexins in the VTA and NAc in drug reward. The apparatus for the CPP was consisted of two distinctive compartments. The 135 male Wistar rats were alternatively treated with morphine (3mg/kg) or saline before conditioning training (45min), with one injection per day. Before three conditioning sessions with morphine, the 0XR1 antagonist SB334867 was bilaterally microinjected into the VTA (0,1, 5μg) or NAcSh (0,1, 3μ.g). Before two conditioning sessions with morphine, orexin A (0,2,4,6μg) was bilaterally microinjected into the NAcSh. One-way ANOVA and Post Hoc LSD were used to reveal the difference among groups.The results showed that the development of morphine CPP was inhibited when SB334867 was infused into the VTA and not affected when SB334867 was infused into the NAcSh. Orexin A microinjected into the NAcSh did not enhance or inhibit morphine CPP, but increased locomotor activity especially in the rats treated with morphine.The present study demonstrated the different roles of orexins in the VTA and NAcSh in drug reward induced by morphine, indicating that orexins in these two brain regions might regulate the different aspects of addictive behavior. |
来源
|
心理学报
,2009,41(4):329-336 【核心库】
|
关键词
|
条件性位置偏爱
;
食欲素
;
中脑腹侧被盖区
;
伏隔核
;
OXB1拮抗剂
|
地址
|
中国科学院心理研究所, 心理健康重点实验室, 北京, 100101
|
语种
|
中文 |
ISSN
|
0439-755X |
学科
|
社会科学总论 |
基金
|
中国科学院西部之光人才培养计划
;
国家自然科学基金
;
国家973计划
;
中国科学院知识创新工程重要方向项目
|
文献收藏号
|
CSCD:3510899
|
参考文献 共
21
共2页
|
1.
Borghnd,S.L. Orexinn A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
NEURON,2006,49(4):589-601
|
CSCD被引
1
次
|
|
|
|
2.
Cluderay,J.E. Protein distribution of the orexin-2 receptor in the rat central nervous system.
Regulatory Peptides,2002,104(1/3):131-144
|
CSCD被引
7
次
|
|
|
|
3.
De Lecea,L. The hypocretins:Hypothalamus-specific peptides with neuroexcitatory activity.
Proceedings of the National Academy of Sciences of the United,1998
|
CSCD被引
1
次
|
|
|
|
4.
Di Chiara,G. Dopamine and drug addiction:the nucleus accumbens shell connection.
NEUROPHARMACOLOGY,2004,47(SuppL1):227-241
|
CSCD被引
10
次
|
|
|
|
5.
DiLeone,R J. Lateral hypothalamic neuropeptides in reward and drug addiction.
Life Sciences,2003,73(6):759-768
|
CSCD被引
6
次
|
|
|
|
6.
Fadel,J. Anatomical substrates of orexin-dopamine interactions:Lateral hypothalamic projections to the ventral tegmental area.
NEUROSCIENCE,2002,111(2):379-387
|
CSCD被引
6
次
|
|
|
|
7.
Georgeseu,D. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.
Journal of Neuroscience,2003,23(8):3106-3111
|
CSCD被引
1
次
|
|
|
|
8.
Harris,G.C. Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward.
Behavioural Brain Research,2007,183(1):43-51
|
CSCD被引
1
次
|
|
|
|
9.
Kelley,A.E. Ventral striatal control of appetitive motivation:role in ingestive behavior and reward-related learning.
Neuroscience and Biobehavioral Reviews,2004,27(8):765-776
|
CSCD被引
14
次
|
|
|
|
10.
Korotkova,T.M. Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins.
Journal of Neuroscience,2003,23(1):7-11
|
CSCD被引
9
次
|
|
|
|
11.
Kotani,A. Rote of orexin receptors in the nucleus accumbens in dopaminedependent turning behaviour of rats.
NEUROPHARMACOLOGY,2008,54(3):613-619
|
CSCD被引
1
次
|
|
|
|
12.
Narita,M. Direct involvement of orexinergic systems in the activation of the mesolimbic depamine pathway and related behaviors induced by morphine.
Journal of Neuroscience,2006,26(2):398-405
|
CSCD被引
7
次
|
|
|
|
13.
Peyron,C. Neurons containing hypocretin(orexin)project to multiple neuronal systems.
Journal ofNeuroscience,1998,18(23):9996-10015
|
CSCD被引
33
次
|
|
|
|
14.
Sakurai,T. Orexins and orexin receptors:A family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior.
CELL,1998,92(4):573-585
|
CSCD被引
129
次
|
|
|
|
15.
Siegel,J.M. Hypocretin(orexin):Role in normal behavior and neuropathology.
Annual Review of Psychology,2004,55:125-148
|
CSCD被引
4
次
|
|
|
|
16.
Thomas,M.J. Synaptic plasticity in the mesolimbic dopamine system.Philosophical transactions of the Royal Society of London.
Series B Biological sciences,2003,358(1432):815-819
|
CSCD被引
1
次
|
|
|
|
17.
Thorpe,A.I. Orexin Ain the nucleus accumbens stimulates feeding and locomotor activity.
Brain Research,2005,1050(1/2):156-162
|
CSCD被引
1
次
|
|
|
|
18.
Tzschentke,T.M. Measuring reward with the conditioned place preference paradigm:a comprehensive review of drug effects,recent progress and new issues.
Progress in Neurobiology,1998,56:613-672
|
CSCD被引
24
次
|
|
|
|
19.
Vanderschuren,L.J. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization:a critical review of preclinical studies.
Psychopharmacology(Berl,2000,151(2/3):99-120
|
CSCD被引
14
次
|
|
|
|
20.
Wise,R.A. A psychomotor stimulant theory of addiction.
Psychological Review,1987,94(4):469-492
|
CSCD被引
14
次
|
|
|
|
|