阻碍条件性恐惧记忆消退的原因分析
Reasons Block Extinction of Conditioned Fear Memory
查看参考文献53篇
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文摘
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创伤后应激障碍是个体经历严重应激后形成的一种焦虑障碍,对其治疗的关键是消退由创伤应激导致的条件性恐惧记忆,但目前最有效的暴露疗法并不能真正有效地抑制患者恐惧记忆的表达。对条件性恐惧的动物模型研究发现情绪性增强效应、恐惧记忆二级条件化与再巩固、内侧前额叶皮层功能不足等均能够阻碍条件性恐惧记忆的消退。针对这几个方面可以探索治疗创伤后应激障碍的相应方法。 |
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其他语种文摘
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Posttraumatic stress disorder is a kind of anxiety disorder which developed after severe trauma. The key of treatment for this disorder is to extinct the conditioned fear memory acquired in trauma. But the most effective exposure therapy can’t repress fear memory efficiently. Researches from animal model of fear conditioning showed that: enhancing effects of emotional arousal, secondary-order conditioning and reconsolidation of fear memory, deficient function of medial prefrontal cortex etc all are reasons block the extinction of fear memory. According to these reasons,corresponding treatment ways can be explored and developed. |
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来源
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心理科学进展
,2009,17(1):126-131 【扩展库】
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关键词
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条件性恐惧记忆
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消退
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情绪性增强效应
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二级条件化
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再巩固
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内侧前额叶皮层
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地址
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中国科学院心理研究所, 心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1671-3710 |
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学科
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社会科学总论 |
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基金
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国家自然科学基金
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中国科学院心理研究所科学发展基金资助
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文献收藏号
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CSCD:3493966
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参考文献 共
53
共3页
|
|
1.
Barrett D. Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response.
J Neurosci,2003,23(13):5740-5749
|
CSCD被引
4
次
|
|
|
|
|
2.
Bouton M E. A modern learning theory perspective on the etiology of panic disorder.
Psychol Rev,2001,108(1):4-32
|
CSCD被引
9
次
|
|
|
|
|
3.
Bradley R. A multidimensional recta-analysis of psychotherapy for PTSD.
Am J Psychiatry,2005,162(2):214-227
|
CSCD被引
17
次
|
|
|
|
|
4.
Bremner J D. Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexualabuse-related post-tranmatic stress disorder.
Psychol Med,2005,35(6):791-806
|
CSCD被引
8
次
|
|
|
|
|
5.
Cohen H. Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder:a double-blind, placebocontrolled study.
Am J Psychiatry,2004,161(3):515-524
|
CSCD被引
12
次
|
|
|
|
|
6.
Davis M. Effects of D-cycloserine on extinction:translation from preclinical to clinical work.
Biol Psychiatry,2006,60(4):369-375
|
CSCD被引
3
次
|
|
|
|
|
7.
Debiec J. Cellular and systems reconsolidation in the hippocampus.
Neuron,2002,36(3):527-538
|
CSCD被引
10
次
|
|
|
|
|
8.
Eisenberg M. Reconsolidation of fresh, remote, and extinguished fear memory in Medaka:old fears don't die.
Eur J Neurosci,2004,20(12):3397-3403
|
CSCD被引
2
次
|
|
|
|
|
9.
Hener F. Vivid memories of emotional events:the accuracy of remembered minutiae.
Mere Cognit,1990,18(5):496-506
|
CSCD被引
1
次
|
|
|
|
|
10.
Kansinger E A. Remembering emotional experiences:the contribution of valence and arousal.
Rev Neursci,2004,15(4):241-251
|
CSCD被引
1
次
|
|
|
|
|
11.
Knight D C. Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning.
Cogn Affect Behav Neurosci,2004,4(3):317-325
|
CSCD被引
3
次
|
|
|
|
|
12.
LaBar K S. Cognitive neuroscience of emotional memory.
Nat Rev Neurosci,2006,7(1):54-64
|
CSCD被引
46
次
|
|
|
|
|
13.
Lebron K. Delayed recall of fear extinction in rats with lesions of ventral me, dial prefrontal cortex.
Learn Mere,2004,11(5):544-548
|
CSCD被引
3
次
|
|
|
|
|
14.
Maren S. Recent fear is resistant to extinction.
Proc Natl Acad Sci USA,2006,103(47):18020-18025
|
CSCD被引
7
次
|
|
|
|
|
15.
McDonald A J. Projections of the medial and lateral prefrontal cortices to the amygdala:a Phaseolus vulgaris lencoagglutinin study in the rat.
Neuroscience,1996,71(1):55-75
|
CSCD被引
7
次
|
|
|
|
|
16.
McGaugh J L. Memory-a century of consolidation.
Science,2000,287(5451):248-251
|
CSCD被引
53
次
|
|
|
|
|
17.
McGaugh J L. The amygdala modulates the consolidation of memories of emotionally arousing experiences.
Annu Rev, Neurosci,2004,27:1-28
|
CSCD被引
28
次
|
|
|
|
|
18.
Milad M R. Neurons in medial prefrontal cortex signal memory for fear extinction.
Nature,2002,420(6911):70-74
|
CSCD被引
25
次
|
|
|
|
|
19.
Milad M R. Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.
Behav Neurosci,2004,118(2):389-394
|
CSCD被引
4
次
|
|
|
|
|
20.
Milad M R. Fear extinction in rats:implications for human brain imaging and anxiety disorders.
Biol Psychol,2006,73:61-71
|
CSCD被引
12
次
|
|
|
|
|
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