Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents
查看参考文献13篇
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文摘
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A series of novel alkylthio/sulfinyl-8H-thieno[2,3-b]pyrrolizin-8-oximino derivatives Ⅴ_1--Ⅷ_(15) were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ~1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ_9 displayed a promising antitumor activity superior to that of Cisplatin. |
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来源
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Chemical Research in Chinese Universities
,2008,24(1):47-53 【核心库】
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DOI
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10.1016/s1005-9040(08)60011-2
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关键词
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Thieno[2,3-b] pyrrolizine
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Synthesis
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Antitumor activity
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地址
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School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1005-9040 |
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学科
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药学 |
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文献收藏号
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CSCD:3251192
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