Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid
查看参考文献12篇
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文摘
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Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ~1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group. |
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来源
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Chemical Research in Chinese Universities
,2008,24(1):42-46 【核心库】
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DOI
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10.1016/s1005-9040(08)60010-0
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关键词
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Ursolic acid
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Amide derivatives
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Anti-tumor activity
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地址
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1.
College of Pharmaceuticals ＆ Biotechnology, Tianjin University, Tianjin, 300072
2.
Faculty of Pharmaceutical Engineering，Shenyang Institute of Chemical Technology, Shenyang, 110142
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1005-9040 |
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学科
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药学 |
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基金
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辽宁省自然科学基金
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Science and Technology Foundation of Shenyang City of China（No.20050785）.
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文献收藏号
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CSCD:3251191
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