细胞因子与抑郁症发病机制研究进展
查看参考文献28篇
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文摘
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抑郁症是目前危害人类健康的主要疾病之一,对其病因机制的探讨是达到有效治疗的必要途径.近几年来,研究热点逐渐由神经递质和神经内分泌激素转向对细胞因子的关注.抑郁症的免疫异常自七十年代就有报道;九十年代以来,随着研究技术的发展,发现抑郁症常有炎性分子增高,提示免疫激活.近年来这方面的研究趋向于认为抑郁症的发生可能与免疫激活导致细胞因子分泌增多有关,提出了抑郁症的"细胞因子假说".该假说强调抑郁症是一种心理神经免疫紊乱性障碍. |
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来源
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中国神经精神疾病杂志
,2007,33(9):572-574 【核心库】
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关键词
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细胞因子
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单胺类神经递质
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HPA轴
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神经可塑性
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抑郁症
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地址
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中国科学院心理研究所, 北京, 100101
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语种
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中文 |
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文献类型
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综述型 |
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ISSN
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1002-0152 |
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学科
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基础医学;神经病学与精神病学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:2925455
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28
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