Growth Inhibition of Breast Cancer in Rat by AAV Mediated Angiostatin Gene
查看参考文献12篇
文摘
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Objective: To observe growth inhibition effect of adeno-associated viral vectors (AAV) mediated angiostatin (ANG) gene on implanted breast cancer in rat and its mechanism. Methods: Gene transfer technique was used to transfer AAV-ANG to the tumor. Growth curves were drawn to observe the growth of breast cancer implanted in rat, and immunohistochemical method was used to detect the effects of angiostatin on microvesel density (MVD) of breast cancer implanted in rat. Results: Angiostatin inhibited the growth of breast cancer implanted in rat and decreased the microvessel density of tumor. Conclusion: Expression of an angiostatin transgene can suppress the growth of breast cancer implanted in rat through the inhibition of the growth of microvessels, surggesting that angiostatin gene transfer technique may be effective against breast cancer. |
来源
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Chinese Journal of Cancer Research
,2007,19(2):108-112 【核心库】
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关键词
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AAV-ANG
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Breast cancer
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Growth inhibition
;
Microvessel density
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地址
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Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang, 110001
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语种
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英文 |
文献类型
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研究性论文 |
ISSN
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1000-9604 |
学科
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肿瘤学 |
文献收藏号
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CSCD:2911737
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