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Growth Inhibition of Breast Cancer in Rat by AAV Mediated Angiostatin Gene

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文摘 Objective: To observe growth inhibition effect of adeno-associated viral vectors (AAV) mediated angiostatin (ANG) gene on implanted breast cancer in rat and its mechanism. Methods: Gene transfer technique was used to transfer AAV-ANG to the tumor. Growth curves were drawn to observe the growth of breast cancer implanted in rat, and immunohistochemical method was used to detect the effects of angiostatin on microvesel density (MVD) of breast cancer implanted in rat. Results: Angiostatin inhibited the growth of breast cancer implanted in rat and decreased the microvessel density of tumor. Conclusion: Expression of an angiostatin transgene can suppress the growth of breast cancer implanted in rat through the inhibition of the growth of microvessels, surggesting that angiostatin gene transfer technique may be effective against breast cancer.
来源 Chinese Journal of Cancer Research ,2007,19(2):108-112 【核心库】
关键词 AAV-ANG ; Breast cancer ; Growth inhibition ; Microvessel density
地址

Cancer Research Institute, The First Affiliated Hospital, China Medical University, Shenyang, 110001

语种 英文
文献类型 研究性论文
ISSN 1000-9604
学科 肿瘤学
文献收藏号 CSCD:2911737

参考文献 共 12 共1页

1.  SAUER G. Angiogenesis:prognostic and therapeutic implications in gynecologic and breast malignancies. Curr Opin Obstet Gynecol,2003,15:45-49 CSCD被引 2    
2.  Tao KS. Expression of angiostatin cDNA in human hepatocellular carcinoma cell line SMMC-7721 and its effect on implanted carcinoma in nude mice. World J Gastroenterol,2004,10:1424 CSCD被引 1    
3.  Lowenfels AB. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep,2005,7:90-95 CSCD被引 4    
4.  Tatyana Isayeva. Recombinant adeno-associated wirus 2-mediated antiangiogenic prevention in a mouse model of intraperitoneal ovarian cancer. Clin Cancer Res,2005,11:1342-1347 CSCD被引 1    
5.  Kurup A. Recombinant human angiostatin(rhAngiostatin)in combination with paxlitaxel and carboplatin in patients with advanced non-small-cell lungcancer:a phaseⅡstudy from Indiana University. Ann Oncol,2006,17:97-103 CSCD被引 5    
6.  Wu Jing. Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice. World J Gastroenterol,2003,9:59-64 CSCD被引 5    
7.  Tsui KH. Renal cell carcinoma:prognostic significance of incidentally detected tumors. J Urol,2000,163:426-430 CSCD被引 8    
8.  Papetti M. Mechanisms of normal and tumor-derived angiogenesis. Am J pHysiol Cell Physiol,2002,282:947-970 CSCD被引 21    
9.  Ellis LM. Overview of angiogenesis:Biologic implications for antiangiogenic therapy. Semin Oncol,2001,28(16):94-104 CSCD被引 1    
10.  Cavallaro U. Molecular mechanisms of tumor angiogenesis and tumor progression. J Neuro Oncol,2000,50:63-70 CSCD被引 7    
11.  Dixelius J. Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res,2002,62:1944-1947 CSCD被引 6    
12.  Izumi Y. tumor biology:herceptin acts as anti-angiogenic cocktail. Nature,2002,416:279-280 CSCD被引 16    
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1 卓建新 反义细胞周期蛋白B1重组AAV抑制骨肉瘤U2OS细胞增殖和诱导凋亡 解剖学报,2009,40(3):414-418
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