Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats
Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats
查看参考文献13篇
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文摘
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Aim： To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. Methods： After administration of two typical dosage forms （daidzein solution and suspension）, the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student＇s t-test. Results： Absorption of daidzein after administration of daidzein solution （tmax=0.46 h） was more rapid than that of the suspension （tmax=5.00 h）. The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 μg/L and 127.3 μg/L, respectively, and those of daidzein-7-O-glucuronide were 3000 μg/L and 192.6 μg/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein （free plus conjugated daidzein）. Conclusion： Absorption of daidzein solution was better than absorption of suspension （P〈0.05）. |
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来源
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Acta Pharmacologica Sinica
,2005,26(9):1145-1152 【核心库】
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DOI
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10.1111/j.1745-7254.2005.00187.x
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关键词
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daidzein
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daidzein-7-O-glucuronide
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influence
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dosage forms
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pharmacokinetics
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rats
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地址
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1.
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 辽宁, Shenyang, 110016
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Tianjin Institute of Pharmaceutical Research, Tianjin Key Laboratory of Drug Metabolism and Pharmacokinetics, Tianjin, 300193
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1671-4083 |
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学科
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药学 |
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基金
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国家自然科学基金
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文献收藏号
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CSCD:2208518
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