柴达木盆地唐古特白刺籽油保护肝损伤作用研究
The Protective Effect of Nitraria tangutorum Bobr. Seed Oil from Qaidam Basin on the Liver Injury of Mice

索有瑞 ¹ 高航 ² 王洪伦 ¹

文摘	对柴达木盆地唐古特白刺种籽油保护化学性肝损伤作用进行了研究.将小鼠按体重随机分为白刺籽油高、中、低剂量组,另设空白对照组和联苯双酯、藏茵陈阳性对照组.小鼠连续灌胃给药15 d后,用CCl4进行肝损伤,测定小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST);肝脏过氧化脂质(LPO)降解产物丙二醛(MDA)和谷胱甘肽过氧化物酶(GSH-Px)的含量.结果显示,白刺籽油对血清ALT、AST具有显著的抑制作用,显著拮抗肝脏MDA的升高,显著提高肝脏GSH-Px含量.表明白刺籽油具有明显的保护化学性肝损伤的保健作用.
其他语种文摘	The protective effect of seed oil of Nitraria tangutorum Bobr. from Qingliai Qaidam Basin. On tlie liver injury by chemical reagent was studied in this paper.The mice were randomly divided into three experimental groups according to their weiglit, the normal control group, two comparison groups of Sivertia mussotii and diphenyl bibenzoate. After rats were feed seed oil for 15 days,their liver were injured by CCLi.The content of ALT, AST in serum and the content of MDA,GSH-Px in liver were measured. Tlie result showed that tlie seed oil could obviously control the content of ALT, AST in serum, prevent the rise of MDA in liver and enhance the content of GSH-Px in liver.The result indicated tliat the seed oil of Nitraria tangutorum Bobr. lias significant protective effect on the mice.
来源	天然产物研究与开发 ,2005,17(5):573-576 【核心库】
关键词	唐古特白刺 ; 种籽油 ; 化学性肝损伤 ; 保护作用
地址	1. 中国科学院西北高原生物研究所, 青海, 西宁, 810001 2. 中国科学院广州地球化学研究所, 广东, 广州, 510640
语种	中文
文献类型	研究性论文
ISSN	1001-6880
学科	植物学;中国医学
基金	中国科学院西部之光人才培养计划
文献收藏号	CSCD:2134308