Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
查看参考文献29篇
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文摘
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Aim: Recent studies have shown that l-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization. |
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来源
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Acta Pharmacologica Sinica
,2005,26(5):533-538 【核心库】
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DOI
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10.1111/j.1745-7254.2005.00101.x
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关键词
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l-tetrahydropalmatine
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oxycodone
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loco-motor sensitization
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地址
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1.
Beijing Institute of Pharmacology and Toxicology, Beijing, 100850
2.
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing, 100083
3.
Department of Pharmacology, Shenyang Pharmaceutical University, 辽宁, Shenyang, 110016
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语种
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英文 |
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文献类型
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研究性论文 |
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ISSN
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1671-4083 |
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学科
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药学 |
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文献收藏号
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CSCD:2038650
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