多巴胺D1受体参与吗啡介导的小鸡条件性位置偏爱的表达
INVOLVEMENT OF DOPAMINE D1 RECEPTORS ON THE EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN CHICKS
查看参考文献13篇
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文摘
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目的:利用条件性位置偏爱模型探求吗啡对小鸡的奖赏作用及其相关的多巴胺机制.方法:ip 2mg?kg-1吗啡对小鸡进行4次条件化训练后进行条件性位置偏爱测试,测试前15min分别ip生理盐水、0.25mg?kg-1多巴胺D1受体拮抗剂SCH23390或者等剂量的多巴胺D2受体拮抗剂雷氯必利(raclopride),观察其干预效果.结果:吗啡诱导出小鸡的条件性位置偏爱(P＜0.01),条件性位置偏爱的表达被SCH23390阻断(P＜0.05),而不受雷氯必利的影响(P＞0.05).结论:吗啡的奖赏作用在鸟类中也有体现,小鸡可以成为研究药物成瘾的合适的模型.多巴胺D1受体可能参与对吗啡药物渴求的形成. |
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其他语种文摘
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Objective: To investigate the rewarding effect of morphine on newly hatched chicks and the role of dopaminergic mechanisms on the expression of morphine - induced place preference. Methods: Newly hatched male chicks were administrated with morphine (2 mg'kg"1, intraperitoneally) for 4 condition-ing trials, 0.25 mg-kg" dopamine D, receptor antagonist SCH23390 or the same dose of D2 receptor antago-nist raclopride intraperitoneally injected before the expression of place preference. Results: Morphine produced conditioned place preference(CPP) on chicks(P < 0.01). The injection of SCH23390 (P < 0.05) but not raclopride(P > 0.05) abolished the expression of morphine - induced CPP. Conclusion: These results suggest that the rewarding effects of morphine may be highly conserved across species. Chicks might serve as an alter-native animal model for investigating drugs of abuse. These data also indicate that D, receptor is critically in-volved in morphine - induced craving. |
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来源
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中国药物依赖性杂志
,2004,13(2):96-99 【扩展库】
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关键词
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吗啡
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条件性位置偏爱
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渴求
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多巴胺
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小鸡
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地址
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中科院心理所, 心理健康重点实验室, 北京, 100101
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1007-9718 |
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学科
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畜牧、动物医学、狩猎、蚕、蜂 |
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基金
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国家自然科学基金
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中国科学院知识创新工程项目
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文献收藏号
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CSCD:1509806
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参考文献 共
13
共1页
|
|
1.
刘闯. 药物渴求.
中国药物依赖性杂志,1999,8(1):19-22
|
CSCD被引
9
次
|
|
|
|
|
2.
Berke J D. Addiction.
Neuron,2000,25:515-532
|
CSCD被引
52
次
|
|
|
|
|
3.
Nestler E J. Total recall- the memory of addiction[J].
Science,2001,292:2266-2267
|
CSCD被引
24
次
|
|
|
|
|
4.
Levens N. Cocaine induces conditioned place preference and increases locomotor activity in male Japanese quail[J].
Pharmacol Biochem Behav,2001,68:71-80
|
CSCD被引
3
次
|
|
|
|
|
5.
Bronson M E. Morphine.
Exp Clin Psychopharmacol,1996,4:352-362
|
CSCD被引
3
次
|
|
|
|
|
6.
Darland T. Behavioral screening for cocaine sensitivity in mutagenized zebrafish[J].
Proc Natl Acad Sci USA,2001,98(20):11691-11696
|
CSCD被引
13
次
|
|
|
|
|
7.
Bainton R J. Dopamine modulates acute responses to cocaine.
Current Biology,2000,10:187-194
|
CSCD被引
2
次
|
|
|
|
|
8.
Dichiara G. differential role in behavior and addiction[J].
Behav Brain Res,2002,137:75-114
|
CSCD被引
1
次
|
|
|
|
|
9.
Yanagihara S. Reward-related neuronal activity in basal gangalia of domestic chicks[J].
Neuroreport,2001,12:1431-1435
|
CSCD被引
1
次
|
|
|
|
|
10.
Durstewitz D. Teh dopaminergic innervation of the avian telencephalon[J].
Prog Neurobiol,1999,59:161-196
|
CSCD被引
4
次
|
|
|
|
|
11.
Manzanedo C. Effects of dopamine antagonists with different receptor blockade profiles on morphine- induced place preference in male mice[J].
Behav Brain Res,2001,121(1/2):189-197
|
CSCD被引
6
次
|
|
|
|
|
12.
Rezayof A. Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine - induced place preference in rat[J].
Pharmacol Biochem Behav,2002,74:187-197
|
CSCD被引
3
次
|
|
|
|
|
13.
Bardo M T. a meta- analysis[J].
Neurosci Biobehav Bev,1995,19(1):39-51
|
CSCD被引
5
次
|
|
|
|
|
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