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文摘
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目的：通过观察藏药1号水提液对大鼠离体胸动脉条收缩作用的影响研究其降压机制。方法：观察藏药1号水提液（6mg/mL）和维拉帕米（Ver0.013mg/mL）对高K~+液引起的主动脉条收缩的时效影响，对KCL，NE及CaCl-2引起的大鼠主动脉条收缩的量效曲线的影响，以及对NE引起的依赖于细胞内钙及细胞外钙的收缩的影响。结果：藏药1号水提液意志K~+液引起的主动脉收缩；且可使KCl、NE及CaCl-2引起的大鼠的主动脉条收缩的量效曲线非平行右移，最大效应降低，呈非竞争性拮抗作用；与维拉帕米相似，对NE引起的依赖于细胞内钙及细胞外钙的收缩均有抑制作用。结论：提示藏药1号的降压机制与钙离子通道拮抗剂一致 |
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其他语种文摘
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To study the influence of aqueous extract from Zang Yao-I(AEZY-I)on inhibition to the contractions induced by KCl,NE,CaCl-2 in isolated rat thoracic aortic rings,and uncover the mechanism of antihypertensive effect of Zang Yao-I.Methods:Recording the dose-response curves induced by KCl,NE,CaCl-2,and the next dose-response curves again after AEZY-I being added,respectively.Results:AEZY-I inhibited the contractions evoked by KCl,NE,CaCl-2 in isolated rat thoracic aortic rings.Significantly,AEZY-I could depress the maximal response and cause rightward displacement of the dose-reponse curves,and resulted of a non-competitive antagonism mechanism .In Ca~(2+)free solution,AEZY-I inhibited contraction in aortic rings,which is dependent on Ca~(2+) relased from not only intracellular store but also extracellular Ca~(2+).Therefore,AEZY-I inhibited both the potential dependent channel and the receptor operated channel.Conclusion:AEZY-I could relax the contraction of isolated rat thoracic aortic rings,and so the mechanism of antihypertensive of Zang Yao-I is related to its antagonistic effect on calcium ion |
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来源
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中药药理与临床
,2003,19(2):43-45 【扩展库】
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关键词
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藏药1号
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大鼠离体主动脉条
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维拉帕米
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地址
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1.
中国科学院西部北高原生物研究所, 西宁, 810001
2.
北京心肺疾病研究所 北京安贞医院高血压研究室, 北京, 100039
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中国科学院西北高原生物研究所, 西宁, 810001
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1001-859X |
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学科
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中国医学 |
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文献收藏号
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CSCD:1355654
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