功能磁共振成像对高血压患者注意功能的评价研究
Assessment on the changes of attention in patients with hypertensio by functional MRI
查看参考文献22篇
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文摘
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目的 应用与Stroop字色干扰测验相似的Simon任务和事件相关设计fMRI技术，探讨高血压对注意功能的影响及其相关的神经生物学基础。方法 采用Siemens公司Sonata 1.5 T 磁共振成像系统，对12位无神经体征，年龄在50～65岁的中老年原发高血压患者[血压≥140/90 mm Hg (1 mm Hg=0.133kPa)或正服用降压药物]和12位年龄、性别、利手、受教育年限及职业类型相匹配的正常对照组，在执行注意任务测试的同时进行全脑扫描。采用t检验对两组行为作业的反应时和反应正确率进行统计学分析。脑功能成像数据经头动矫正、空间标准化、空间平滑等预处理后，通过反卷积计算获得注意任务不同情况下的脑激活统计参数图。采用一般线性检验(general linear test)计算组间和任务间的脑激活的差异。结果 高血压组反应时间和反应的正确率[(547±271) ms，(78±25)%]与正常对照组[(529±321)ms，(89±8)%]之间差异无显著性意义(t=0.870，P=0.865；t=-1.597，P=0.121)，但高血压组各研究对象正确率均数的标准误(6.51)明显高于正常对照组(2.22)。高血压组脑激活区信号明显强于对照组，以双侧前额区皮质为著。结论 fMRI可以比临床和行为测量方法更敏感地探测到高血压对脑功能影响，特别是早期或轻度的功能缺陷。 |
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其他语种文摘
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Objective To study the characteristic brain activation involved in attention in hypertension patients by performing the Simon task which is similar to stroop task, and by using event-related functional MRI (fMRI). Methods The study sample consisted of 2 groups: 12 stroke- and dementia-free hypertension patients aged 50 to 65 years, and 12 matched healthy old subjects. fMRI was scanned on a Sonata 1.5 T scanner (Siemens) while they were performing attention tasks. The t-test was used to analyze the behavioral data between the two groups. Image data were motion corrected and spatially normalized according to the standard coordinates, and spatially smoothed with isotopic Guassian Kernel. Activation maps for attention conditions were generated respectively by deconvolve analysis. The general linear test was used to compare the cortex activation pattern and different active areas between tasks and groups. Results There were no significant differences between hypertension patients [ (547 ±271) ms, (78 ±25)% ] and control group [ (529 ± 321) ms, (89 ± 8) % ] in reaction times and accuracy when performing attention tasks (t = 0.870, P=0.865;f= -1.597, P=0.121). But the standard error of mean of the patient's accuracy rate (6.51) was significantly higher than that of the control group (2. 22). Functional imaging data showed significantly greater activation in the patients compared with control group while performing the same task, especially in the prefrontal cortex ( BA 6, 9, and 10). Conclusion fMRI appears to be more sensitive than neurological and neuropsychological evaluations in early hypertension-associated cognitive impairments. |
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来源
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中华放射学杂志
,2003,37(10):887-891 【核心库】
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关键词
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高血压
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认知
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磁共振成像
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评价研究
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地址
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1.
首都医科大学附属安贞医院放射科, 北京, 100029
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中国科学院心理研究所, 中科院脑高级功能实验室
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语种
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中文 |
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文献类型
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研究性论文 |
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ISSN
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1005-1201 |
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学科
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特种医学 |
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文献收藏号
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CSCD:1263448
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