事件相关功能MRI在随意运动脑功能活动区协同作用研究中的应用
The cooperation of the functional activation areas in human brain: an application of event-related fMRI study of the voluntary motor function
查看参考文献14篇
文摘
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目的 应用事件相关功能磁共振成像(fMRI)技术,探讨手指运动时人脑功能活动区的协同作用。方法 选取44名健康受试者,应用信息提示-执行(CUE-GO)行为模式,成像应用GE Signa Iorizon 1.5T磁共振系统,所获数据在SUN与SGI工作站进行处理。结果 对侧初级运动皮层(M1),双侧辅助运动区(SMA)、运动前区(PMA)、基底节及小脑皮质等区域有明显激活。其中M1区时间-信号强度曲线呈典型单峰曲线;PMA、基底节、小脑皮质区的时间-信号强度曲线为双峰曲线。SMA又分为2个区,为位于前方的辅助运动前区(Pre-SMA)和后方固有区(SMA Proper)。Pre-SMA为双峰曲线,SMA Proper则为单峰曲线。各脑区的时间-信号强度曲线不完全相同。结论 (1)M1区为运动执行区;而其他脑区则参与运动准备及运动执行,且各脑区在其功能上有一定差异。(2)SMA、PMA、基底节及小脑皮质均为双侧激活,与传统理论略有差异。(3)事件相关fMRI技术具有较高的时间分辨率和空间分辨率。(4)脑内不同脑区、基底节及小脑间其功能活动具有协同作用。 |
其他语种文摘
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Objective To detect the cooperation of the functional activation areas in human brain using event-related fMRI technique developed in recent years. Methods Forty-four subjects were selected in this experiment and scanned by GE Signa Horizon 1.5 Tesla superconductive MR system. A CUE-GO paradigm was used in this experiment. The data were analyzed in SUN and SGI workstation. Results The activation areas were found in contralateral primary motor area(Ml),bilateral supplementary motor areas(SMA),premotor areas(PMA), basal ganglia, and cerebellar cortices. The time-signal curve of Ml was a typical single-peak curve, but the curves in PMA, basal ganglia, and cerebellar cortices were double-peak curves. SMA had 2 parts, one was Pre-SMA, and another was SMA Proper. The curve was double-peak type in Pre-SMA and single-peak type in SMA Proper. There was difference between the time-signal intensity curves in above-mentioned areas. Conclusion (1) Ml is mainly associated with motor execution, while others with both motor preparation and execution. There are differences in the function at the variant areas in the brain. (2)The fact that bilateral SMA, PMA, basal ganglia, and cerebellar cortices were activated, is different from what the classical theories told. (3) Event-related fMRI technique has higher temporary and spatial resolutions. (4)There is cooperation among different cortical areas, basal ganglia, and cerebellum. |
来源
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中华放射学杂志
,2002,36(5):397-401 【核心库】
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关键词
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事件相关功能
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MRI
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随意运动
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脑功能
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协同作用
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研究
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磁共振成像
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地址
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1.
中国科学院自动化研究所人工智能研究室, 北京, 100080
2.
首都钢铁公司总医院神经内科
3.
中国科学院心理研究高级脑功能研究实验室
4.
首都钢铁公司总医院影像科
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首都钢铁公司总医院声像室
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语种
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中文 |
文献类型
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研究性论文 |
ISSN
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1005-1201 |
学科
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临床医学 |
基金
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国家自然科学基金
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北京市优秀人才培养资助项目
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文献收藏号
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CSCD:1101121
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